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What exactly does it mean when a person has a high PSA level?

By Lisa Fayed, About.com

Updated: April 21, 2007

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Question: What exactly does it mean when a person has a high PSA level?
Answer: The PSA is a test used to measure a substance called prostate specific antigen in the blood. It is used as a screening tool for prostate cancer.

In a healthy male, the PSA should be less than 4 nanograms per milliliter of blood. Anything higher than 4 can indicate prostate cancer.

Keep in mind that PSA tests are notorious for producing false positives. Other tests such as a biopsy or DRE may be performed to further evaluate the prostate for cancer.

There are other factors that can elevate the PSA levels, such as:

  • ejaculation (no ejaculation at least two days prior to test)

  • PSA levels can naturally increase with age

  • inflammation of the prostate gland

  • non cancerous enlargement of the prostate

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