Since we know more about what increases the risk of endometrial cancer, risk reduction methods are more plentiful. Long-term use of oral contraceptives and maintaining a healthy weight are both methods is reducing your risk of developing endometrial cancer. Because endometrial cancer is fueled by estrogen, using a hormone replacement therapy during menopause that contains progestin along with estrogen may decrease a woman's risk. This type of hormone therapy does have side effects and is not for everyone.
Even with endometrial cancer, you cannot avoid risk factors like previous tamoxifen use to treat breast cancer. A physician or patient would never reject the use of tamoxifen based on the slight risk of developing endometrial cancer in the future. The risk simply does not outweigh the benefits.
Sources:
American Cancer Society. What is Uterine Sarcoma? A Detailed Guide. !9 June 2006. Accessed August 10, 2008.
http://www.cancer.org/Cancer/UterineSarcoma/DetailedGuide/uterine-sarcoma-what-is-uterine-sarcoma
National Cancer Institute. Uterine Sarcoma. 26 June 2008. Accessed 9 Aug 2008.
http://www.cancer.gov/cancertopics/types/uterinesarcoma
